MERIT: MEtabolic Reprogramming in viral pathogenesis: From Infection to Therapeutic innovations

Contribution: Coordinator

The MERIT consortium aims to shift virology from a traditional virus-centric approach to one that better incorporates host biology. The primary objective of the consortium is to understand the complex interplay between viruses and host cells, with a focus on metabolic reprogramming and the long-term consequences of infection. This will be achieved through an interdisciplinary approach that incorporates three methodological pillars, viz., organotypic models (organoids), integrative and spatial omics, and advanced (super-resolution) microscopy. The organotypic models will serve as miniaturised in vitro models that mimic the human genetic and tissue-specific context, enabling the study of organ-specific processes in viral pathogenesis. Integrative omics will provide a comprehensive understanding of virus-host interactions by combining data from diverse approaches, allowing the dissection of specific mechanisms. Spatial omics will result in the precise localisation of molecular changes within the tissue architecture. Advanced microscopy techniques (super-resolution optical microscopy, label-free 3D tomography, autofluorescence microscopy, and Raman microspectroscopy) will bridge the gap between molecular data and cellular-level events, offering unprecedented visualisation of cells in the tissue context. By integrating these state-of-the-art techniques, the consortium will not only advance fundamental virology research but also contribute to the development of novel therapeutic strategies that address both immediate and long-term impacts of infections. The research's relevance to the MSCA doctoral programme lies in its innovative training approach, which aims to equip researchers with cutting-edge skills to address emerging infectious diseases. The MERIT researchers will take a more holistic approach to virology, thereby ensuring pandemic preparedness and elevating the EU's position in this field.